CSF sTREM2 in neurological diseases: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been described as a biomarker for microglial activation, which were observed increased in a variety of neurological disorders.

Objective

Our objective was to explore whether genetically determined CSF sTREM2 levels are causally associated with different neurological diseases by conducting a two-sample Mendelian randomization (MR) study.

Methods

Single nucleotide polymorphisms significantly associated with CSF sTREM2 levels were selected as instrumental variables to estimate the causal effects on clinically common neurological diseases, including stroke, Alzheimer's diseases, Parkinson's diseases, amyotrophic lateral sclerosis, multiple sclerosis, and epilepsy

SUBMITTER: Dong MH 

PROVIDER: S-EPMC8985278 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature