Spinal cord injury: a study protocol for a systematic review and meta-analysis of microRNA alterations.

ABSTRACT:

Background

Spinal cord injury (SCI) is a devastating condition with no current neurorestorative treatments. Clinical trials have been hampered by a lack of meaningful diagnostic and prognostic markers of injury severity and neurologic recovery. Objective biomarkers and novel therapies for SCI represent urgent unmet clinical needs. Biomarkers of SCI that objectively stratify the severity of cord damage could expand the depth and scope of clinical trials and represent targets for the development of novel therapies for acute SCI. MicroRNAs (miRNAs) represent promising candidates both as informative molecules of injury severity and recovery, and as therapeutic targets. miRNAs are small, regulatory RNA molecules that are tissue-specific and evolutionarily conserved across species. miRNA

SUBMITTER: Tigchelaar S 

PROVIDER: S-EPMC8985297 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature