Neurite dispersion and density mediates the relationship between cardiorespiratory fitness and cognition in healthy younger adults.

ABSTRACT: Growing evidence suggests physical activity and cardiorespiratory fitness are associated with better cognition across the lifespan. However, the neurobiological underpinnings relating fitness and cognition remain unclear, particularly in healthy younger adults. Using a well-established and popular multi-compartment diffusion modeling approach, called Neurite Orientation and Dispersion and Density Imaging (NODDI), we investigated the relationship between physical fitness (measured via a 2-min walk test), cognition (fluid and crystallized), and gray and white matter microstructure, in a large sample (n = 816) of healthy younger adults (ages 22-35 years) from the human connectome project (HCP). Concurrent with previous literature, we found that fitness was positively associated with both flui

SUBMITTER: Callow DD 

PROVIDER: S-EPMC8985444 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature