Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease.

ABSTRACT:

Background

Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by intracellular accumulations of α-synuclein and nerve cell loss in striatonigral and olivopontocerebellar structures. Epidemiological and clinical studies have reported potential involvement of autoimmune mechanisms in MSA pathogenesis. However, genetic etiology of this interaction remains unknown. We aimed to investigate genetic overlap between MSA and 7 autoimmune diseases and to identify shared genetic loci.

Methods

Genome-wide association study summary statistics of MSA and 7 autoimmune diseases were combined in cross-trait conjunctional false discovery rate analysis to explore overlapping genetic background. Expression of selected candidate genes was compared in transgenic MSA m

SUBMITTER: Shadrin AA 

PROVIDER: S-EPMC8985479 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature