A personalized medicine approach to ovulation induction/ovarian stimulation: development of a predictive model and online calculator from level-I evidence.

ABSTRACT:

Objective

To estimate the probability of clinical or multiple pregnancy during ovulation induction (OI)/ovarian stimulation (OS).

Design

Secondary analysis of two multicenter randomized clinical trials (combined).

Setting

Multicenter.

Patients

A total of 750 women with polycystic ovary syndrome and 900 women with unexplained infertility.

Interventions

Ovulation induction/OS with either timed intercourse (polycystic ovary syndrome) or intrauterine insemination.

Main outcome measures

Clinical and multiple pregnancy rates/cycle, cumulative pregnancy rates. Age, body mass index, parity, diagnosis, medication, markers of ovarian reserve, and ovarian response were considered in multivariable regression models for clinical, multiple, and cumulative pregn

SUBMITTER: Souter I 

PROVIDER: S-EPMC8985501 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature