Bridging D-A type photosensitizers with the azo group to boost intersystem crossing for efficient photodynamic therapy.

ABSTRACT: Photodynamic therapy (PDT) has attracted much attention in disease treatments. However, the exploration of a novel method for the construction of outstanding photosensitizers (PSs) with stimuli-responsiveness remains challenging. In this study, we, for the first time, report a novel and effective strategy to boost reactive oxygen species (ROS) generation by bridging donor-acceptor (D-A) type PSs with the azo group. In contrast to the counterpart without azo-bridging, the azo-bridged PSs exhibit remarkably enhanced ROS generation via both type-I and type-II photochemical reactions. Theoretical calculations suggest that azo-bridging leads to a prominent reduction in ΔE _ST, thereby enabling enhanced ROS generation via efficient intersystem crossing (ISC). The r

SUBMITTER: Hao B 

PROVIDER: S-EPMC8985587 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature