Heterogeneity of germline variants in high risk breast and ovarian cancer susceptibility genes in India.

ABSTRACT: Breast and ovarian cancers now account for one in three cancers in Indian women and their incidence is rising. Major differences in the clinical presentation of breast and ovarian cancers exist between India and the United Kingdom. For example, Indian patients with breast cancer typically present a decade earlier than in the UK. Reasons for this could be multifactorial, including differences in underlying biology, environmental risks, and other systematic factors including access to screening. One possible explanation lies in variable incidence or penetrance of germline mutations in genes such as BRCA1 and BRCA2. We performed a methodical database and literature review to investigate the prevalence and spectrum of high-risk cancer susceptibility genes in Indian patients with breast and ova

SUBMITTER: Sharma-Oates A 

PROVIDER: S-EPMC8985795 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature