Surface conjugation of antibodies improves nanoparticle uptake in bronchial epithelial cells.

ABSTRACT:

Background

Advances in Molecular Therapy have made gene editing through systemic or topical administration of reagents a feasible strategy to treat genetic diseases in a rational manner. Encapsulation of therapeutic agents in nanoparticles can improve intracellular delivery of therapeutic agents, provided that the nanoparticles are efficiently taken up within the target cells. In prior work we had established proof-of-principle that nanoparticles carrying gene editing reagents can mediate site-specific gene editing in fetal and adult animals in vivo that results in functional disease improvement in rodent models of β-thalassemia and cystic fibrosis. Modification of the surface of nanoparticles to include targeting molecules (e.g. antibodies) holds the promise of improving cellular

SUBMITTER: Luks VL 

PROVIDER: S-EPMC8986008 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature