Clinical Validation of an Immune Quiescence Gene Expression Signature in Kidney Transplantation.

ABSTRACT:

Background

Despite advances in immune suppression, kidney allograft rejection and other injuries remain a significant clinical concern, particularly with regards to long-term allograft survival. Evaluation of immune activity can provide information about rejection status and help guide interventions to extend allograft life. Here, we describe the validation of a blood gene expression classifier developed to differentiate immune quiescence from both T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR).

Methods

A five-gene classifier (DCAF12, MARCH8, FLT3, IL1R2, and PDCD1) was developed on 56 peripheral blood samples and validated on two sample sets independent of the training cohort. The primary validation set comprised 98 quiescence samples and 18 rejecti

SUBMITTER: Akalin E 

PROVIDER: S-EPMC8986041 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature