Validating a Computable Phenotype for Nephrotic Syndrome in Children and Adults Using PCORnet Data.

ABSTRACT:

Background

Primary nephrotic syndromes are rare diseases which can impede adequate sample size for observational patient-oriented research and clinical trial enrollment. A computable phenotype may be powerful in identifying patients with these diseases for research across multiple institutions.

Methods

A comprehensive algorithm of inclusion and exclusion ICD-9 and ICD-10 codes to identify patients with primary nephrotic syndrome was developed. The algorithm was executed against the PCORnet CDM at three institutions from January 1, 2009 to January 1, 2018, where a random selection of 50 cases and 50 noncases (individuals not meeting case criteria seen within the same calendar year and within 5 years of age of a case) were reviewed by a nephrologist, for a total of 150 cases a

SUBMITTER: Oliverio AL 

PROVIDER: S-EPMC8986057 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature