Human antibodies against noncircumsporozoite proteins block Plasmodium falciparum parasite development in hepatocytes.

ABSTRACT: Sporozoite-based approaches currently represent the most effective vaccine strategies for induction of sterile protection against Plasmodium falciparum (Pf) malaria. Clinical development of subunit vaccines is almost exclusively centered on the circum-sporozoite protein (CSP), an abundantly expressed protein on the sporozoite membrane. Anti-CSP antibodies are able to block sporozoite invasion and development in human hepatocytes and subsequently prevent clinical malaria. Here, we have investigated whether sporozoite-induced human antibodies with specificities different from CSP can reduce Pf-liver stage development. IgG preparations were obtained from 12 volunteers inoculated with a protective immunization regime of whole sporozoites under chloroquine prophylaxis. These IgGs were depleted

SUBMITTER: Fabra-Garcia A 

PROVIDER: S-EPMC8986077 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature