Disc and Actin Associated Protein 1 influences attachment in the intestinal parasite Giardia lamblia.

ABSTRACT: The deep-branching eukaryote Giardia lamblia is an extracellular parasite that attaches to the host intestine via a microtubule-based structure called the ventral disc. Control of attachment is mediated in part by the movement of two regions of the ventral disc that either permit or exclude the passage of fluid under the disc. Several known disc-associated proteins (DAPs) contribute to disc structure and function, but no force-generating protein has been identified among them. We recently identified several Giardia actin (GlActin) interacting proteins at the ventral disc, which could potentially employ actin polymerization for force generation and disc conformational changes. One of these proteins, Disc and Actin Associated Protein 1 (DAAP1), is highly enriched at the two regions of the di

SUBMITTER: Steele-Ogus MC 

PROVIDER: S-EPMC8986099 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature