Breast-conserving therapy is associated with better survival than mastectomy in Early-stage breast cancer: A propensity score analysis.

ABSTRACT:

Background

Recent retrospective studies have reported that breast-conserving therapy (BCT) led to improved overall survival (OS) than mastectomy in some populations. We aimed to compare the efficacy of BCT and mastectomy using the SEER database.

Materials and methods

Between 2010 and 2015, 99,790 eligible patients were identified. We included early-stage breast cancer patients with 5cm or smaller tumors and three or fewer positive lymph nodes in our study. We compared the OS and breast cancer-specific survival (BCSS) results among patients with BCT and those with mastectomy. Kaplan-Meier plots, Cox proportional hazard regressions, competing risk analysis, and multivariate regressions were used to evaluate the outcomes. Propensity-score matching was used to assemble a cohort

SUBMITTER: Ji J 

PROVIDER: S-EPMC8986144 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature