Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins.

ABSTRACT: Cyclic AMP is a ubiquitous second messenger used to transduce intracellular signals from a variety of Gs-coupled receptors. Compartmentalisation of protein intermediates within the cAMP signaling pathway underpins receptor-specific responses. The cAMP effector proteins protein-kinase A and EPAC are found in complexes that also contain phosphodiesterases whose presence ensures a coordinated cellular response to receptor activation events. Popeye domain containing (POPDC) proteins are the most recent class of cAMP effectors to be identified and have crucial roles in cardiac pacemaking and conduction. We report the first observation that POPDC proteins exist in complexes with members of the PDE4 family in cardiac myocytes. We show that POPDC1 preferentially binds the PDE4A sub-family via a sp

SUBMITTER: Tibbo AJ 

PROVIDER: S-EPMC8986152 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature