A novel group of genes that cause endocrine resistance in breast cancer identified by dynamic gene expression analysis.

ABSTRACT: Breast cancer (BC) is the most common type of cancer diagnosed in women. Among female cancer deaths, BC is the second leading cause of death worldwide. For estrogen receptor-positive (ER-positive) breast cancers, endocrine therapy is an effective therapeutic approach. However, in many cases, an ER-positive tumor becomes unresponsive to endocrine therapy, and tumor regrowth occurs after treatment. While some genetic mutations contribute to resistance in some patients, the underlying causes of resistance to endocrine therapy are mostly undetermined. In this study, we utilized a recently developed statistical approach to investigate the dynamic behavior of gene expression during the development of endocrine resistance and identified a novel group of genes whose time course expression signific

SUBMITTER: Asghari A 

PROVIDER: S-EPMC8986262 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature