Integrated RNA-Seq Analysis Uncovers the Potential Mechanism of the "Kidney Governing Bones" Theory of TCM.

ABSTRACT:

Background

As in philosophy of traditional Chinese medicine (TCM), the theory of "kidney governing bones" has been demonstrated by a series of scientific studies. Furthermore, many groups including ours have explored the molecular mechanisms related to bone development, growth, and regeneration using modern biology technologies, such as RNA sequencing (RNA-Seq) and isobaric tags for relative and absolute quantification (ITRAQ), and have demonstrated that the underlying molecular mechanisms were highly consistent with the "kidney governing bones" theory.

Objective

Kidney-yang deficiency (YD), as a pathological condition, has a passive effect on the skeleton growth; more specifically, it is a state of skeletal metabolic disorder. However, the exact molecular mechanisms related

SUBMITTER: Yang S 

PROVIDER: S-EPMC8986393 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature