B-cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells.

ABSTRACT: The random recombination of immunoglobulin V(D)J gene segments produces unique IgM antibodies that serve as the antigen receptor for each developing B cell. Hence, the newly formed B cell repertoire is comprised of a variety of specificities that display a range of reactivity with self-antigens. Newly generated IgM⁺ immature B cells that are non-autoreactive or that bind self-antigen with low avidity are licensed to leave the bone marrow with their intact antigen receptor and to travel via the blood to the peripheral lymphoid tissue for further selection and maturation. In contrast, clones with medium to high avidity for self-antigen remain within the marrow and undergo central tolerance, a process that revises their antigen receptor or eliminates the autoreactive B cell altoget

SUBMITTER: Pelanda R 

PROVIDER: S-EPMC8986553 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature