Estimation of Contrast Agent Concentration in DCE-MRI Using 2 Flip Angles.

ABSTRACT:

Purpose

The aim of this study was to investigate the feasibility of using 2 flip angles (FAs) with an ultrashort echo time during dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) for estimation of plasma gadolinium (Gd) concentration without using a precontrast longitudinal relaxation time T1 (T10) measurement.

Methods

T1-weighted DCE-MRI experiments were carried out with C57BL/6J mice using the scan protocol with 2 FAs over 3 sequential segments during 1 scan. The data with 2 FAs were used to estimate T10 (T1T) during conversion of a time-intensity curve to the time-concentration curve. Three dosages of gadolinium-based contrast agent were used to achieve a wide range of variability in Gd concentrations when measured at 10 minutes postinjection: 0.05 mmol/kg

SUBMITTER: Bharadwaj Das A 

PROVIDER: S-EPMC8986601 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature