Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load.

ABSTRACT: Set-point viral load (SPVL), a common measure of human immunodeficiency virus (HIV)-1 virulence, is partially determined by viral genotype. Epidemiological evidence suggests that this viral property has been under stabilising selection, with a typical optimum for the virus between 10⁴ and 10⁵ copies of viral RNA per ml. Here we aimed to detect transmission fitness differences between viruses from individuals with different SPVLs directly from phylogenetic trees inferred from whole-genome sequences. We used the local branching index (LBI) as a proxy for transmission fitness. We found that LBI is more sensitive to differences in infectiousness than to differences in the duration of the infectious state. By analysing subtype-B samples from the Bridging the Evolution and

SUBMITTER: Zhao L 

PROVIDER: S-EPMC8986633 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature