On the interrelation between alcohol addiction-like behaviors in rats.

ABSTRACT:

Rationale

Alcohol use disorder (AUD) is a complex, heterogeneous disorder that only occurs in a minority of alcohol users. Various behavioral constructs, including excessive intake, habit formation, motivation for alcohol and resistance to punishment have been implicated in AUD, but their interrelatedness is unclear.

Objective

The aim of this study was therefore to explore the relation between these AUD-associated behavioral constructs in rats. We hypothesised that a subpopulation of animals could be identified that, based on these measures, display consistent AUD-like behavior.

Methods

Lister Hooded rats (n = 47) were characterised for alcohol consumption, habit formation, motivation for alcohol and quinine-adulterated alcohol consumption. The interrelation between t

SUBMITTER: Smeets JAS 

PROVIDER: S-EPMC8986720 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature