TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis.

ABSTRACT: Tumor necrosis factor-α-induced protein 8 (TNFAIP8 or TIPE) is a member of the TNFAIP8 family. While TIPE was broadly considered to be pro-cancerous, its precise roles in carcinogenesis especially those of the intestinal tract are not clear. Here, we show that genetic deletion of TIPE in mice exacerbated chemical-induced colitis and colitis-associated colon cancer. Loss of TIPE exacerbated inflammatory responses and inflammation-associated dysbiosis, leading to the activation of NF-κB and STAT3, and it also accelerated dysplasia, DNA damage and proliferation of intestinal epithelial cells. We further show that colon microbiota were essential for increased tumor growth and progression in Tipe^-/- mice. The tumor suppressive function of TIPE originated primarily from the non-hemato

SUBMITTER: Lou Y 

PROVIDER: S-EPMC8986800 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature