Naturally occurring combinations of receptors from single cell transcriptomics in endothelial cells.

ABSTRACT: VEGF inhibitor drugs are part of standard care in oncology and ophthalmology, but not all patients respond to them. Combinations of drugs are likely to be needed for more effective therapies of angiogenesis-related diseases. In this paper we describe naturally occurring combinations of receptors in endothelial cells that might help to understand how cells communicate and to identify targets for drug combinations. We also develop and share a new software tool called DECNEO to identify them. Single-cell gene expression data are used to identify a set of co-expressed endothelial cell receptors, conserved among species (mice and humans) and enriched, within a network, of connections to up-regulated genes. This set includes several receptors previously shown to play a role in angiogenesis. Mult

SUBMITTER: Domanskyi S 

PROVIDER: S-EPMC8987085 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature