Identification of New Biological Pathways Involved in Skin Aging From the Analysis of French Women Genome-Wide Data.

ABSTRACT: Skin aging is an ineluctable process leading to the progressive loss of tissue integrity and is characterized by various outcomes such as wrinkling and sagging. Researchers have identified impacting environmental factors (sun exposure, smoking, etc.) and several molecular mechanisms leading to skin aging. We have previously performed genome-wide association studies (GWAS) in 502 very-well characterized French women, looking for associations with four major outcomes of skin aging, namely, photoaging, solar lentigines, wrinkling, and sagging, and this has led to new insights into the molecular mechanisms of skin aging. Since individual SNP associations in GWAS explain only a small fraction of the genetic impact in complex polygenic phenotypes, we have made the integration of these genotypes

SUBMITTER: Rahmouni M 

PROVIDER: S-EPMC8987498 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature