A diagnostic test: combined detection of heparin-binding protein, procalcitonin, and C-reactive protein to improve the diagnostic accuracy of bacterial respiratory tract infections.

ABSTRACT:

Background

Respiratory tract infection (RTI) is one of the most common diseases worldwide, and its incidence is rising year by year due to environmental pollution. Sputum culture remains the gold standard for RTI diagnosis, but its performance is limited by difficulties related to the sampling and testing of the sputum specimens. Heparin-binding protein (HBP), procalcitonin (PCT), and C-reaction protein (CRP) are Inflammatory markers. They have the advantage of being fast, accurate and reproducible, but limited by their sensitivity and specificity. We explored the clinical value of the combined detection of them in the diagnosis of bacterial RTIs.

Methods

Patients who fulfilled the inclusion criteria were selected as the case group, healthy age- and sex-matched subjects were

SUBMITTER: Ma J 

PROVIDER: S-EPMC8987818 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature