Identification of core genes associated with type 2 diabetes mellitus and gastric cancer by bioinformatics analysis.

ABSTRACT:

Background

Gastric cancer (GC) is the most common type of malignant neoplasm of the digestive system. Diabetes mellitus (DM) or hyperglycemia may increase the incidence or mortality of GC. We aimed to investigate the possible genetic relationship between GC, DM, and type 2 diabetes mellitus (T2DM), and to identify core genes that are associated with T2DM and GC.

Methods

The GeneCards database was used to screen DM-, T2DM-, and GC-related genes, and a protein-protein interaction (PPI) network of the genes/proteins associated with overlapping genes between DM, T2DM, and GC was constructed. Molecular Complex Detection (MCODE) was used to identify the significant module. CytoHubba (U.S. National Institute of General Medical Sciences) was utilized to detect hub genes in the PPI.

SUBMITTER: Liu S 

PROVIDER: S-EPMC8987879 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature