Immune checkpoint inhibitors and adrenal insufficiency: a large-sample case series study.

ABSTRACT:

Background

Adrenal insufficiency (AI) represents a rare, yet potentially life-threatening immune checkpoint inhibitor (ICI)-related adverse event. The clinical characteristics of ICI-induced AI are still poorly defined due to its low incidence but need to be comprehensively understood.

Methods

We systematically retrieved and screened the PubMed/Medline, Embase, Web of Science, and Cochrane Library databases for all articles published on AI related to anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4), anti-programmed cell death protein-1 (PD-1) receptor or its ligand (PD-L1), or combination ICI therapy. The retrieved articles were reviewed and selected in accordance with the exclusion criteria. The detailed data of individual cases were then collected and analyzed.

Results

SUBMITTER: Cui K 

PROVIDER: S-EPMC8987884 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature