Volumetric Brain Loss Correlates With a Relapsing MOGAD Disease Course.

ABSTRACT:

Background

Myelin oligodendrocyte glycoprotein antibody disorders (MOGAD) have evolved as a distinct group of inflammatory, demyelinating diseases of the CNS. MOGAD can present with a monophasic or relapsing disease course with distinct clinical manifestations.However, data on the disease course and disability outcomes of these patients are scarce. We aim to compare brain volumetric changes for MOGAD patients with different disease phenotypes and HCs.

Methods

Brain magnetic resonance imaging (MRI) scans and clinical data were obtained for 22 MOGAD patients and 22 HCs. Volumetric brain information was determined using volBrain and MDbrain platforms.

Results

We found decreased brain volume in MOGAD patients compared to HCs, as identified in volume of total brain, gray m

SUBMITTER: Rechtman A 

PROVIDER: S-EPMC8987978 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature