Consensus Obtained for the Nephrotoxic Potential of 167 Drugs in Adult Critically Ill Patients Using a Modified Delphi Method.

ABSTRACT:

Introduction

The approach to evaluating nephrotoxins in studies of drug-associated acute kidney injury varies. Some studies use a list of under ten drugs for evaluation whereas others include over 100 drugs. Drugs are typically assigned a binary classification, nephrotoxic or not nephrotoxic. This oversimplifies the nephrotoxic potential of the drugs under investigation.

Objective

This study aimed to assign a nephrotoxin potential for 167 drugs used in the adult critical care setting.

Methods

A three-round, international, interdisciplinary, web-based modified-Delphi study was used to evaluate nephrotoxins used in adult critically ill patients. Twenty-four international experienced clinicians were identified through the Acute Disease Quality Initiative group and profes

SUBMITTER: Gray MP 

PROVIDER: S-EPMC8988110 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature