Negative Immune Checkpoint Protein, VISTA, Regulates the CD4⁺ T_reg Population During Sepsis Progression to Promote Acute Sepsis Recovery and Survival.

ABSTRACT: Sepsis is a systemic immune response to infection that is responsible for ~35% of in-hospital deaths and over 24 billion dollars in annual treatment costs. Strategic targeting of non-redundant negative immune checkpoint protein pathways can cater therapeutics to the individual septic patient and improve prognosis. B7-CD28 superfamily member V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an ideal candidate for strategic targeting in sepsis. We hypothesized that immune checkpoint regulator, VISTA, controls T-regulatory cells (T_reg), in response to septic challenge, thus playing a protective role/reducing septic morbidity/mortality. Further, we investigated if changes in morbidity/mortality are due to a T_reg-mediated effect during the acute response t

SUBMITTER: Gray CC 

PROVIDER: S-EPMC8988198 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature