Bidirectional control of infant rat social behavior via dopaminergic innervation of the basolateral amygdala.

ABSTRACT: Social interaction deficits seen in psychiatric disorders emerge in early-life and are most closely linked to aberrant neural circuit function. Due to technical limitations, we have limited understanding of how typical versus pathological social behavior circuits develop. Using a suite of invasive procedures in awake, behaving infant rats, including optogenetics, microdialysis, and microinfusions, we dissected the circuits controlling the gradual increase in social behavior deficits following two complementary procedures-naturalistic harsh maternal care and repeated shock alone or with an anesthetized mother. Whether the mother was the source of the adversity (naturalistic Scarcity-Adversity) or merely present during the adversity (repeated shock with mom), both conditions elevated basolat

SUBMITTER: Opendak M 

PROVIDER: S-EPMC8988217 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature