Antibiotic Chlortetracycline Causes Transgenerational Immunosuppression via NF-κB.

ABSTRACT: The extensive and increasing global use of antibiotics results in the ubiquitous presence of antibiotics in the environment, which has made them "pseudo persistent organic contaminants." Despite numerous studies showing wide adverse effects of antibiotics on organisms, the chronic environmental risk of their exposure is unknown, and the molecular and cellular mechanisms of antibiotic toxicity remain unclear. Here, we systematically quantified transgenerational immune disturbances after chronic parental exposure to environmental levels of a common antibiotic, chlortetracycline (CTC), using zebrafish as a model. CTC strongly reduced the antibacterial activities of fish offspring by transgenerational immunosuppression. Both innate and adaptive immunities of the offspring were suppressed, show

SUBMITTER: Qiu W 

PROVIDER: S-EPMC8988297 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature