Safety assessment of graphene oxide and microcystin-LR complex: a toxicological scenario beyond physical mixture.

ABSTRACT:

Background

Nanomaterials have been widely used in electrochemistry, sensors, medicine among others applications, causing its inevitable environmental exposure. A raising question is the "carrier" effect due to unique surface properties of nanomaterials, which may collectively impact the bioavailability, toxicokinetic, distribution and biological effects of classic toxicants. Noteworthy, this aspect of information remains largely unexplored.

Methods

Here, we deliberately selected two entities to mimic this scenario. One is graphene oxide (GO), which is made in ton quantity with huge surface-area that provides hydrophilicity and π-π interaction to certain chemicals of unique structures. The other is Microcystin-LR (MCLR), a representative double-bond rich liver-toxic endotoxin

SUBMITTER: Ma Y 

PROVIDER: S-EPMC8988332 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature