Early-life exposure to Chinese famine and stroke risk in mid- to late life: the mediating roles of cognitive function and depression.

ABSTRACT:

Background

Limited research has examined the role that famine exposure plays in adulthood stroke risk. We aim to explore the causal implications of early exposure to the Great Chinese Famine on stroke risk and determine whether these associations were mediated by cognitive function, and depression.

Methods

We sampled 12,681 individuals aged 45 years and older from the China Health and Retirement Longitudinal Study (CHARLS) and divided them into fetally exposed, childhood-exposed, adolescence/adulthood-exposed and unexposed groups. Stroke was defined by self- or proxy-reported physician diagnosis. Based on a counterfactual framework, marginal structural models were used to estimate the natural direct effect and the natural indirect effects through cognitive function and depre

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC8988351 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature