Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged App^{NL-G-F/NL-G-F} mice.

ABSTRACT: As the proportion of elderly in society increases, so do the number of older patients undergoing surgical procedures. This is concerning as exposure to anesthesia has been identified as a risk factor for Alzheimer's disease (AD). However, the causal relationship between clinical AD development and anesthesia remains conjectural. Preclinical studies have demonstrated that anesthesia, such as halothane, isoflurane, and sevoflurane, induces AD-like pathophysiological changes and cognitive impairments in transgenic mouse models of AD. Desflurane does not have these effects and is expected to have more potential for use in elderly patients, yet little is known about its effects, especially on non-cognitive functions, such as motor and emotional functions. Thus, we examined the postanesthetic ef

SUBMITTER: Niikura R 

PROVIDER: S-EPMC8988377 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature