Pharmacologically induced weight loss is associated with distinct gut microbiome changes in obese rats.

ABSTRACT:

Background

Obesity, metabolic disease and some psychiatric conditions are associated with changes to relative abundance of bacterial species and specific genes in the faecal microbiome. Little is known about the impact of pharmacologically induced weight loss on distinct microbiome species and their respective gene programs in obese individuals.

Methodology

Using shotgun metagenomics, the composition of the microbiome was obtained for two cohorts of obese female Wistar rats (n = 10-12, total of 82) maintained on a high fat diet before and after a 42-day treatment with a panel of four investigatory or approved anti-obesity drugs (tacrolimus/FK506, bupropion, naltrexone and sibutramine), alone or in combination.

Results

Only sibutramine treatment induced consistent weig

SUBMITTER: Raineri S 

PROVIDER: S-EPMC8988407 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature