Impact of Decipher on use of post-operative radiotherapy: Individual patient analysis of two prospective registries.

ABSTRACT:

Objective

To assess the association between Genomic Classifier (GC)-risk group and post-radical prostatectomy treatment in clinical practice.

Methods

Two prospective observational cohorts of men with prostate cancer (PCa) who underwent RP in two referral centers and had GC testing post-prostatectomy between 2013 and 2018 were included. The primary endpoint of the study was to assess the association between GC-risk group and time to secondary therapy. Univariable (UVA) and multivariable (MVA) Cox proportional hazards models were constructed to assess the association between GC-risk group and time to receipt of secondary therapy after RP, where secondary therapy is defined as receiving either RT or ADT after RP.

Results

A total of 398 patients are included in the analys

SUBMITTER: Shahait M 

PROVIDER: S-EPMC8988525 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature