Activity of 3,19-isopropylidinyl andrographolide against herpes simplex virus type 1 in an animal model.

ABSTRACT:

Background

In our previous study, the semi-synthetic analog of andrographolide, 3,19-isopropylideneandrographolide (IPAD), acts more effectively against herpes simplex virus (HSV) infection in cell culture than does acyclovir. IPAD inhibits cytopathic effect and production of HSV wild types and drug-resistant strains. Its effect is associated with the reduction of immediate-early regulatory protein (ICP27) and early proteins (ICP8 and UL42), indicating a mode of action different from that of acyclovir. Therefore, studies of the anti-HSV activity of IPAD in animal models are required before further application.

Material & method

Prednisolone-treated BALB/c mice were cutaneously infected with HSV-1 wild-type KOS strain. Experimental groups included control groups (untreated or

SUBMITTER: Chuerduangphui J 

PROVIDER: S-EPMC8988668 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature