Performance of prostate health index and PSA density in a diverse biopsy-naive cohort with mpMRI for detecting significant prostate cancer.

ABSTRACT:

Objective

To compare Prostate Health Index (PHI) and prostate-specific antigen (PSA) density as secondary tests after multiparametric magnetic resonance imaging (mpMRI) in improving the detection accuracy of Gleason grade group (GG) 2-5 prostate cancer (PCa) and in decreasing unnecessary biopsies in a multiethnic biopsy-naïve population.

Methods

From February 2017 to February 2020, we recruited consecutive biopsy-naïve men in participating urology clinics for elevated PSA levels. They all had a PHI score, mpMRI, and prostate biopsy. Experienced genitourinary radiologists read all mpMRI studies based on PIRADS version 2.0. Logistic regression models were used to generate receiver operating characteristic curves. Models were tested for effect modification between Race (Black v

SUBMITTER: Carbunaru S 

PROVIDER: S-EPMC8988695 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature