Effect of advanced glycation end products on nocturia or sleep disorders: A longitudinal study.

ABSTRACT:

Objective

This study aimed to investigate the effect of advanced glycation end products (AGEs) on nocturia and sleep disorders in community-dwelling adults.

Materials and methods

This longitudinal study evaluated AGEs level, sleep disorders and nocturia frequency in 447 community-dwelling adults between May 2011 and May 2016. Sleep disorders were evaluated using the Pittsburgh Sleep Quality Index (PSQI) score. Participants were divided into two groups: AGEs-low (≤1.80) and AGEs-high (>1.80). The longitudinal nocturia and PSQI changes for 5 years between the AGEs-low and AGEs-high groups were compared. The effect of baseline oxidative stress on worsening of nocturia or PSQI score 5 years later was evaluated using multivariable logistic regression analyses.

Results

Ther

SUBMITTER: Konishi S 

PROVIDER: S-EPMC8988819 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature