Multimodal kidney-preserving approach in localised and locally advanced high-risk upper tract urothelial carcinoma.

ABSTRACT:

Objectives

Multimodal kidney-preserving (MKP) strategies may be an option for patients with localised or locally advanced high-risk upper tract urothelial carcinoma (UTUC) who have a relative contraindication for nephroureterectomy (NU).

Materials and methods

We studied patients with UTUC who were managed with MKP strategies, consisting of systemic anticancer therapy, with or without local/topical strategies after endoscopic control of intraluminal tumours. Primary end points were overall survival (OS) and progression-free survival (PFS).

Results

Fourteen patients received MKP treatment between August 2013 and April 2020. Median baseline estimated glomerular filtration rate was 43 mL/min/1.73m². MKP was mainly pursued to avoid dialysis (10/14, 71%), followe

SUBMITTER: Alhalabi O 

PROVIDER: S-EPMC8988842 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature