Dihydromyricetin improves social isolation-induced cognitive impairments and astrocytic changes in mice.

ABSTRACT: Social isolation induces stress, anxiety, and mild cognitive impairment that could progress towards irreversible brain damage. A probable player in the mechanism of social isolation-induced anxiety is astrocytes, specialized glial cells that support proper brain function. Using a social isolation mouse model, we observed worsened cognitive and memory abilities with reductions of Object Recognition Index (ORI) in novel object recognition test and Recognition Index (RI) in novel context recognition test. Social isolation also increased astrocyte density, reduced astrocyte size with shorter branches, and reduced morphological complexity in the hippocampus. Dihydromyricetin, a flavonoid that we previously demonstrated to have anxiolytic properties, improved memory/cognition and restored astroc

SUBMITTER: Watanabe S 

PROVIDER: S-EPMC8989100 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature