The VarA-CsrA regulatory pathway influences cell shape in Vibrio cholerae.

ABSTRACT: Despite extensive studies on the curve-shaped bacterium Vibrio cholerae, the causative agent of the diarrheal disease cholera, its virulence-associated regulatory two-component signal transduction system VarS/VarA is not well understood. This pathway, which mainly signals through the downstream protein CsrA, is highly conserved among gamma-proteobacteria, indicating there is likely a broader function of this system beyond virulence regulation. In this study, we investigated the VarA-CsrA signaling pathway and discovered a previously unrecognized link to the shape of the bacterium. We observed that varA-deficient V. cholerae cells showed an abnormal spherical morphology during late-stage growth. Through peptidoglycan (PG) composition analyses, we discovered that these mutant bacteria contai

SUBMITTER: Lemos Rocha LF 

PROVIDER: S-EPMC8989286 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature