Engineering selectivity of Cutibacterium acnes phages by epigenetic imprinting.

ABSTRACT: Cutibacterium acnes (C. acnes) is a gram-positive bacterium and a member of the human skin microbiome. Despite being the most abundant skin commensal, certain members have been associated with common inflammatory disorders such as acne vulgaris. The availability of the complete genome sequences from various C. acnes clades have enabled the identification of putative methyltransferases, some of them potentially belonging to restriction-modification (R-M) systems which protect the host of invading DNA. However, little is known on whether these systems are functional in the different C. acnes strains. To investigate the activity of these putative R-M and their relevance in host protective mechanisms, we analyzed the methylome of six representative C. acnes strains by Oxford Nanopore Technolog

SUBMITTER: Knodlseder N 

PROVIDER: S-EPMC8989293 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature