A portable brightfield and fluorescence microscope toward automated malarial parasitemia quantification in thin blood smears.

ABSTRACT: Malaria is often most endemic in remote regions where diagnostic microscopy services are unavailable. In such regions, the use of rapid diagnostic tests fails to quantify parasitemia measurements which reflect the concentration of Plasmodium parasites in the bloodstream. Thus, novel diagnostic and monitoring technologies capable of providing such information could improve the quality of treatment, monitoring, and eradication efforts. A low-cost, portable microscope for gathering quantitative parasitemia data from fluorescently stained thin blood smears is presented. The system employs bimodal imaging using components optimized for cost savings, system robustness, and optical performance. The microscope is novel for its use of monochromatic visible illumination paired with a long working di

SUBMITTER: Gordon PD 

PROVIDER: S-EPMC8989350 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature