Relating the cortical visual contrast gain response to spectroscopy-measured excitatory and inhibitory metabolites in people who experience migraine.

ABSTRACT:

Objective

This study aimed to determine whether the visual response to flickering checkerboard patterns measured using electroencephalography (EEG) relate to excitatory or inhibitory metabolite levels measured using ultra-high (7Tesla/7T) magnetic resonance spectroscopy (MRS).

Background

Electrophysiological studies have shown altered visual cortical response amplitudes and contrast gain responses to high contrast flickering patterns in people with migraine. These contrast response anomalies have been argued to represent an imbalance between cortical inhibition and excitation, however the specific mechanism has not been elucidated.

Methods

MRS-measured metabolite levels were obtained from the occipital cortex of 18 participants with migraine and 18 non-headache contro

SUBMITTER: Chan YM 

PROVIDER: S-EPMC8989360 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature