Boosting of serum neutralizing activity against the Omicron variant among recovered COVID-19 patients by BNT162b2 and CoronaVac vaccines.

ABSTRACT:

Background

SARS-CoV-2 Omicron variant evades immunity from past infection or vaccination and is associated with a greater risk of reinfection among recovered COVID-19 patients. We assessed the serum neutralizing antibody (NAb) activity against Omicron variant (Omicron NAb) among recovered COVID-19 patients with or without vaccination.

Methods

In this prospective cohort study with 135 recovered COVID-19 patients, we determined the serum NAb titers against ancestral virus or variants using a live virus NAb assay. We used the receiver operating characteristic analysis to determine the optimal cutoff for a commercially-available surrogate NAb assay.

Findings

Among recovered COVID-19 patients, the serum live virus geometric mean Omicron NAb titer was statistically signific

SUBMITTER: Lu L 

PROVIDER: S-EPMC8989491 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature