Cardiovascular signatures of COVID-19 predict mortality and identify barrier stabilizing therapies.

ABSTRACT:

Background

Endothelial cell (EC) activation, endotheliitis, vascular permeability, and thrombosis have been observed in patients with severe coronavirus disease 2019 (COVID-19), indicating that the vasculature is affected during the acute stages of SARS-CoV-2 infection. It remains unknown whether circulating vascular markers are sufficient to predict clinical outcomes, are unique to COVID-19, and if vascular permeability can be therapeutically targeted.

Methods

Prospectively evaluating the prevalence of circulating inflammatory, cardiac, and EC activation markers as well as developing a microRNA atlas in 241 unvaccinated patients with suspected SARS-CoV-2 infection allowed for prognostic value assessment using a Random Forest model machine learning approach. Subsequent ex vi

SUBMITTER: Gustafson D 

PROVIDER: S-EPMC8989492 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature