Systematic review of the changes in the microbiome following spinal cord injury: animal and human evidence.

ABSTRACT:

Study design

Systematic review.

Objectives

To investigate the changes in the microbiome among human and animal populations with spinal cord injury (SCI).

Methods

Four databases (EMBASE, Medline (Ovid), Web of Science, Cochrane Central Register of Trials (CENTRAL)) and Google Scholar were searched. No language restrictions were applied. Data extraction was done in parallel and independently by two reviewers. The search was last conducted on 07 April 2021.

Results

There were 6869 studies retrieved, 43 full-text studies reviewed, and 19 studies included. There were seven animal gut studies, six human gut studies, and six urinary tract studies identified. There were no publications found on other body sites. Among the included studies, we observed a consistent and

SUBMITTER: Valido E 

PROVIDER: S-EPMC8989678 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature