Azithromycin reduces inflammation-amplified hypoxic-ischemic brain injury in neonatal rats.

ABSTRACT:

Background

Systemic inflammation amplifies neonatal hypoxic-ischemic (HI) brain injury. Azithromycin (AZ), an antibiotic with anti-inflammatory properties, improves sensorimotor function and reduces tissue damage after neonatal rat HI brain injury. The objective of this study was to determine if AZ is neuroprotective in two neonatal rat models of inflammation-amplified HI brain injury.

Design/methods

Seven-day-old (P7) rats received injections of toll-like receptor agonists lipopolysaccharide (LPS) or Pam₃Cys-Ser-(Lys)₄ (PAM) prior to right carotid ligation followed by 50 min (LPS + HI) or 60 min (PAM + HI) in 8% oxygen. Outcomes included contralateral forelimb function (forepaw placing; grip strength), survival, %Intact right hemisphere (brain damage),

SUBMITTER: Barks JDE 

PROVIDER: S-EPMC8989723 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature