HLA Homozygosity and Likelihood of Sensitization in Kidney Transplant Candidates.

ABSTRACT:

Background

Homozygosity for HLAs has been associated with adverse outcomes after viral infection as well as pregnancy-induced HLA sensitization. We sought to assess the relationship between HLA locus homozygosity and the level of HLA antibody sensitization.

Methods

We measured sensitization using the calculated panel reactive antibody value for a large cohort of 147 461 patients added to the US OPTN/United Network for Organ Sharing kidney transplant waitlist between December 2014 and December 2019. We used multinomial logistic modeling to compare 62 510 sensitized patients to 84 955 unsensitized controls.

Results

We found that the number of homozygous HLA loci was strongly associated with the level of sensitization. Within mildly, highly, or extremely sensitized candi

SUBMITTER: Rushakoff JA 

PROVIDER: S-EPMC8989785 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature